Insulin Granule Segmentation in 3-D TEM Beta Cell Tomograms
نویسندگان
چکیده
David Nam1 [email protected] Judith Mantell2,3 [email protected] David Bull1 [email protected] Paul Verkade2,3,4/shared last author [email protected] Alin Achim1 [email protected] 1 Visual Information Laboratory University of Bristol, UK 2 Wolfson Bioimaging Facility University of Bristol, UK 3 School of Biochemistry University of Bristol, UK 4 School of Physiology and Pharmacology University of Bristol, UK
منابع مشابه
The granular chloride channel ClC-3 is permissive for insulin secretion.
Insulin secretion from pancreatic beta cells is dependent on maturation and acidification of the secretory granule, processes necessary for prohormone convertase cleavage of proinsulin. Previous studies in isolated beta cells revealed that acidification may be dependent on the granule membrane chloride channel ClC-3, in a step permissive for a regulated secretory response. In this study, immuno...
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